L'Unité de recherche Clinique, Innovation, Pharmacologie (URCIP) - Saint-Etienne

Who are we ?

The URCIP (Unité de recherche Clinique, Innovation, Pharmacologie) is a unit of clinical, innovative and pharmacological research of Saint-Etienne University Hospital (https://www.chu-st-etienne.fr/Professionnels/Recherche/Presentation_DRCI/Pro_URCIP.asp). The URCIP is involved in technical-regulatory activities and also provides methodological support, training and monitoring of university hospital research staff. 

Topics of interest

Meta-epidemiology is a tool for taking into account the different methodological characteristics of studies included in systematic reviews. The main interest of meta-epidemiology is to control and quantify potential biases in quantitative systematic reviews, and to derive appropriate results for evidence-based recommendations. Today, networked meta-epidemiology is also being suggested as a way of overcoming some of the limitations of meta-epidemiology. To activate meta-epidemiological studies, tools for managing the risk of bias and any other marker of potential difference linked to the methodology used (single or multi-center study, objective or subjective criteria, qualitative or quantitative, etc.) should be implemented.

Main publications

• Trone JC, Ollier E, Chapelle C, Bertoletti L, Cucherat M, Mismetti P, Magné N, Laporte S. Statistical controversies in clinical research: limitations of open-label studies assessing antiangiogenic therapies with regard to evaluation of vascular adverse drug events-a meta-analysis. Ann Oncol. 2018; 29(4):803-811.
• Laporte S, Chapelle C, Bertoletti L, Ollier E, Zufferey P, Lega JC, Merah A, Décousus H, Schulman S, Meyer G, Cucherat M, Mismetti P. Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta-analysis of randomized controlled trials. J Thromb Haemost. 2017; 15(8):1547-1558.
• Laporte S, Chapelle C, Caillet P, Beyens MN, Bellet F, Delavenne X, Mismetti P, Bertoletti L. Bleeding risk under selective serotonin reuptake inhibitor (SSRI) antidepressants: A meta-analysis of observational studies. Pharmacol Res. 2017; 118:19-32.
• Lega JC, Mismetti P, Cucherat M, Fassier T, Bertoletti L, Chapelle C, Laporte S. Impact of double-blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta-analysis. J Thromb Haemost. 2013; 11(7):1240-50.
• Laporte S, Squifflet P, Baroux N, Fossella F, Georgoulias V, Pujol JL, Douillard JY, Kudoh S, Pignon JP, Quinaux E, Buyse M. Prediction of survival benefits from progression-free survival benefits in advanced non-small-cell lung cancer: evidence from a meta-analysis of 2334 patients from 5 randomised trials. BMJ Open. 2013; 3(3).

Contact 

Unité de recherche Clinique, Innovation, Pharmacologie

CHU Saint-Etienne

Hopital Nord, 42055 Saint-Etienne

silvy.laporte@chuse.fr