Biometry team of CIC-P 1415 - Tours

Who are we ?

The CIC-P 1415 of Tours has a “clinical investigation” component and a “biometry” component. This last one is in charge of methodological, data management and biostatistics activities of clinical studies from the CHRU of Tours. Beside this activity of collaboration around clinical studies, several members of the Biometry team are affiliated to the research team SPHERE (methodS in Patient-centered outcomes and HEalth ResEarch - http://www.sphere-nantes.fr/).

The methodological and biostatistics research thematic of predilection is the one of randomized cluster trials. These trials are defined by the fact that it is not patients that are individually randomized but groups of patients named clusters. The clusters can be hospitals or units, liberal practitioners, families, schools… This study framework is particularly adapted to assess health organization systems, prevention programs, many complex interventions that it is important to study with a rigorous methodology. The implications of clusters randomization are numerous and methodological, biostatistics and even ethical type. These works are made in collaboration with English (Sandra Eldridge and Sally Kerry, University Queen Mary, London - Karla Hemming, University of Birmingham) and Canadian (Monica Taljaard, University of Ottawa - Charles Weijer, Western University, London, Canada) teams.

http://p.cic-tours.fr/

Main publications

• Leyrat C, Caille A, Eldridge S, Kerry S, Dechartres A, Giraudeau B. Intervention effect estimates in cluster randomized versus individually randomized trials: a meta-epidemiological study. Int J Epidemiol. 2018 Nov 9. doi: 10.1093/ije/dyy229.
• Goldstein CE, Giraudeau B, Weijer C, Taljaard M. When and how should we cluster and cross over: methodological and ethical issues. Can J Anaesth. 2018 Jul;65(7):760-765.
• Taljaard M, Hemming K, Shah L, Giraudeau B, Grimshaw JM, Weijer C. Inadequacy of ethical conduct and reporting of stepped wedge cluster randomized trials: Results from a systematic review. Clin Trials. 2017 Aug;14(4):333-341.
• Caille A, Kerry S, Tavernier E, Leyrat C, Eldridge S, Giraudeau B. Timeline cluster: a graphical tool to identify risk of bias in cluster randomised trials. BMJ. 2016 Aug 16;354:i4291.
• Leyrat C, Caille A, Donner A, Giraudeau B. Propensity score methods for estimating relative risks in cluster randomized trials with low-incidence binary outcomes and selection bias. Stat Med. 2014 Sep 10;33(20):3556-75.
• Caille A, Leyrat C, Giraudeau B. A comparison of imputation strategies in cluster randomized trials with missing binary outcomes. Stat Methods Med Res. 2014 Apr 7.
• Leyrat C, Caille A, Donner A, Giraudeau B. Propensity scores used for analysis of cluster randomized trials with selection bias: a simulation study. Stat Med. 2013;32(19):3357-72.
• Caille A, Leyrat C, Giraudeau B. Dichotomizing a continuous outcome in cluster randomized trials: impact on power. Stat Med. 2012 Oct 30;31(24):2822-32.
• Giraudeau B, Caille A, Le Gouge A, Ravaud P. Participant informed consent in cluster randomized trials: review. PLoS One. 2012;7(7):e40436.
• Chosidow O, Giraudeau B, Cottrell J, Izri A, Hofmann R, Mann SG, et al. Oral ivermectin versus malathion lotion for difficult-to-treat head lice. N Engl J Med. 2010;362:896-905.

Contact us

INSERM CIC 1415
2 Bd Tonnellé
37044 Tours cedex 9
02.34.37.96.57